Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
WaveAF01 Exclusive	BRCA-all-q001	6.86e-05	1.53e-04	4.39e-45	1.53e-31
BRCA-all-q001 Exclusive	WaveAF01	2.42e-04	8.79e-04	1.34e-36	4.69e-33
WaveAF01 Exclusive	BRCA-all-q001 Exclusive	1.15e-02	2.19e-02	5.18e-31	5.17e-19
BRCA-all-q001 Exclusive	WaveAF01 Exclusive	2.09e-02	1.01e-02	8.10e-24	6.49e-21
WaveAF01 Exclusive	Overlap	1.15e-03	9.76e-05	2.35e-20	1.21e-17
BRCA-all-q001 Exclusive	Overlap	2.14e-03	3.54e-03	1.07e-15	5.89e-16
Overlap	Exclusives	1.32e-05	6.98e-07	1.52e-65	5.55e-46



Evaluating how well WaveAF01 genes are linked to BRCA-all-q001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveAF01 Exclusive	BRCA-all-q001	0.80	2.43	4.07	4.73	14.99
BRCA-all-q001 Exclusive	WaveAF01	0.83	1.52	4.32	4.53	13.81
WaveAF01 Exclusive	BRCA-all-q001 Exclusive	0.76	1.57	2.64	4.42	9.85
BRCA-all-q001 Exclusive	WaveAF01 Exclusive	0.80	0.92	3.10	4.31	11.19
WaveAF01 Exclusive	Overlap	0.92	3.49	4.74	4.95	9.17
BRCA-all-q001 Exclusive	Overlap	0.91	2.41	3.92	4.29	8.70
Overlap	Exclusives	0.80	3.93	6.03	6.19	14.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveAF01 Exclusive	BRCA-all-q001	0.05	4.61	7.61	17.62	62.93
BRCA-all-q001 Exclusive	WaveAF01	0.04	0.29	6.18	10.12	46.68
WaveAF01 Exclusive	BRCA-all-q001 Exclusive	0.02	3.73	4.72	7.26	11.89
BRCA-all-q001 Exclusive	WaveAF01 Exclusive	0.02	0.12	4.21	7.60	13.04
WaveAF01 Exclusive	Overlap	0.04	3.87	5.70	33.83	75.03
BRCA-all-q001 Exclusive	Overlap	0.02	0.20	5.39	10.18	42.74
Overlap	Exclusives	0.05	3.71	10.15	17.99	51.88

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
WaveAF01 Exclusive	106	106	
BRCA-all-q001 Exclusive	117	116	2021-03-07 00:00:00
Overlap	36	36