Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
WaveAF001 Exclusive	BRCA-all-q01	1.45e-09	6.88e-07	3.17e-81	1.67e-52
BRCA-all-q01 Exclusive	WaveAF001	2.36e-06	6.66e-06	1.36e-50	2.01e-45
WaveAF001 Exclusive	BRCA-all-q01 Exclusive	2.37e-09	5.75e-06	1.93e-69	8.04e-43
BRCA-all-q01 Exclusive	WaveAF001 Exclusive	6.81e-05	3.39e-05	1.68e-41	5.32e-35
WaveAF001 Exclusive	Overlap	3.19e-02	1.50e-01	1.26e-13	1.95e-11
BRCA-all-q01 Exclusive	Overlap	5.45e-03	4.57e-02	9.74e-13	1.13e-12
Overlap	Exclusives	1.37e-04	1.09e-08	1.38e-79	5.75e-57



Evaluating how well WaveAF001 genes are linked to BRCA-all-q01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveAF001 Exclusive	BRCA-all-q01	0.81	3.65	7.11	5.94	16.15
BRCA-all-q01 Exclusive	WaveAF001	0.88	4.04	6.95	6.69	15.19
WaveAF001 Exclusive	BRCA-all-q01 Exclusive	0.80	3.98	6.66	5.81	15.62
BRCA-all-q01 Exclusive	WaveAF001 Exclusive	0.87	4.11	6.29	6.04	15.74
WaveAF001 Exclusive	Overlap	0.90	0.65	1.89	3.31	6.77
BRCA-all-q01 Exclusive	Overlap	0.91	1.51	3.32	3.91	7.39
Overlap	Exclusives	0.79	2.47	6.85	5.54	22.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveAF001 Exclusive	BRCA-all-q01	0.07	5.82	16.80	21.22	60.30
BRCA-all-q01 Exclusive	WaveAF001	0.08	2.73	15.27	16.01	128.75
WaveAF001 Exclusive	BRCA-all-q01 Exclusive	0.06	7.20	14.35	18.45	41.62
BRCA-all-q01 Exclusive	WaveAF001 Exclusive	0.07	3.90	16.75	18.51	102.11
WaveAF001 Exclusive	Overlap	0.02	0.21	3.68	11.29	16.77
BRCA-all-q01 Exclusive	Overlap	0.02	0.21	3.57	8.69	20.52
Overlap	Exclusives	0.07	1.51	7.55	18.11	55.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
WaveAF001 Exclusive	105	105	
BRCA-all-q01 Exclusive	217	214	2021-03-07 00:00:00;DKK 1.00;SOS 1
Overlap	28	28