Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
WaveAF001 Exclusive	BRCA-all-q001	1.35e-07	2.00e-05	8.70e-56	3.03e-36
BRCA-all-q001 Exclusive	WaveAF001	6.16e-07	1.29e-05	2.39e-45	2.00e-41
WaveAF001 Exclusive	BRCA-all-q001 Exclusive	3.88e-08	1.86e-05	1.68e-45	5.46e-29
BRCA-all-q001 Exclusive	WaveAF001 Exclusive	1.36e-04	1.07e-04	9.67e-37	3.96e-32
WaveAF001 Exclusive	Overlap	4.17e-02	2.20e-01	6.01e-12	4.76e-10
BRCA-all-q001 Exclusive	Overlap	1.04e-03	1.98e-02	3.74e-11	9.78e-12
Overlap	Exclusives	3.21e-04	1.02e-06	2.56e-73	3.27e-51



Evaluating how well WaveAF001 genes are linked to BRCA-all-q001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveAF001 Exclusive	BRCA-all-q001	0.82	3.19	5.98	5.59	13.65
BRCA-all-q001 Exclusive	WaveAF001	0.87	3.61	6.66	6.17	14.85
WaveAF001 Exclusive	BRCA-all-q001 Exclusive	0.81	3.77	6.45	5.45	13.96
BRCA-all-q001 Exclusive	WaveAF001 Exclusive	0.86	2.96	5.63	6.04	13.75
WaveAF001 Exclusive	Overlap	0.90	0.27	1.80	3.88	6.68
BRCA-all-q001 Exclusive	Overlap	0.93	2.57	2.90	3.63	6.81
Overlap	Exclusives	0.80	2.64	6.64	5.44	18.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveAF001 Exclusive	BRCA-all-q001	0.05	4.56	10.80	20.75	37.08
BRCA-all-q001 Exclusive	WaveAF001	0.06	0.41	13.28	15.05	42.19
WaveAF001 Exclusive	BRCA-all-q001 Exclusive	0.04	6.30	9.96	15.10	30.20
BRCA-all-q001 Exclusive	WaveAF001 Exclusive	0.05	0.71	14.01	13.35	73.21
WaveAF001 Exclusive	Overlap	0.02	-0.20	3.50	12.62	16.95
BRCA-all-q001 Exclusive	Overlap	0.01	-0.42	5.06	9.96	27.52
Overlap	Exclusives	0.06	3.52	9.21	21.32	72.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
WaveAF001 Exclusive	112	112	
BRCA-all-q001 Exclusive	132	131	2021-03-07 00:00:00
Overlap	21	21