Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
WaveAF0001 Exclusive	BRCA-all-q01	1.28e-06	5.21e-05	4.15e-77	1.68e-47
BRCA-all-q01 Exclusive	WaveAF0001	1.91e-06	8.04e-06	2.18e-50	3.47e-45
WaveAF0001 Exclusive	BRCA-all-q01 Exclusive	2.64e-05	2.67e-04	4.25e-65	8.95e-39
BRCA-all-q01 Exclusive	WaveAF0001 Exclusive	7.50e-05	5.46e-04	7.92e-36	4.51e-31
WaveAF0001 Exclusive	Overlap	4.09e-03	2.21e-03	6.08e-19	1.73e-14
BRCA-all-q01 Exclusive	Overlap	7.16e-03	5.23e-04	3.66e-17	1.24e-16
Overlap	Exclusives	1.09e-08	1.17e-04	1.70e-79	2.50e-57



Evaluating how well WaveAF0001 genes are linked to BRCA-all-q01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveAF0001 Exclusive	BRCA-all-q01	0.80	1.92	5.97	5.30	16.68
BRCA-all-q01 Exclusive	WaveAF0001	0.90	2.11	6.08	5.81	17.41
WaveAF0001 Exclusive	BRCA-all-q01 Exclusive	0.78	1.56	5.72	5.43	13.38
BRCA-all-q01 Exclusive	WaveAF0001 Exclusive	0.88	1.92	4.89	5.04	12.73
WaveAF0001 Exclusive	Overlap	0.92	0.38	2.59	4.02	7.77
BRCA-all-q01 Exclusive	Overlap	0.94	1.92	4.04	3.53	8.46
Overlap	Exclusives	0.80	3.19	7.55	5.87	18.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
WaveAF0001 Exclusive	BRCA-all-q01	0.06	2.86	11.06	16.34	46.29
BRCA-all-q01 Exclusive	WaveAF0001	0.10	0.74	11.83	16.38	185.28
WaveAF0001 Exclusive	BRCA-all-q01 Exclusive	0.05	3.33	8.40	13.89	42.66
BRCA-all-q01 Exclusive	WaveAF0001 Exclusive	0.07	0.40	15.79	14.19	114.02
WaveAF0001 Exclusive	Overlap	0.02	0.16	3.89	19.76	42.06
BRCA-all-q01 Exclusive	Overlap	0.03	0.86	6.10	10.86	79.40
Overlap	Exclusives	0.07	2.04	12.09	17.55	66.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
WaveAF0001 Exclusive	94	94	
BRCA-all-q01 Exclusive	216	213	SOS 1;DKK 1.00;2021-03-07 00:00:00
Overlap	29	29