Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Rare2MethodGenes	AD-GS	1.90e-01	1.12e-01	2.98e-03	2.78e-04
AD-GS	Rare2MethodGenes	4.66e-04	9.36e-01	2.11e-01	1.83e-02



Evaluating how well Rare2MethodGenes genes are linked to AD-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes	AD-GS	0.72	1.62	2.31	1.56	3.69
AD-GS	Rare2MethodGenes	0.57	-0.38	0.41	0.01	3.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes	AD-GS	0.00	0.51	0.09	0.84	2.46
AD-GS	Rare2MethodGenes	0.01	1.09	1.69	1.18	4.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Rare2MethodGenes	152	148	;undefined;C4B_2;SSPO
AD-GS	25	24	HLA -DRB1