Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Reactome-AC4 Exclusive	Somatic	2.35e-04	2.91e-01	1.14e-02	4.69e-11
Somatic Exclusive	Reactome-AC4	6.19e-11	1.31e-02	1.93e-10	7.06e-08
Reactome-AC4 Exclusive	Somatic Exclusive	7.52e-05	2.29e-01	5.97e-02	4.69e-10
Somatic Exclusive	Reactome-AC4 Exclusive	1.04e-11	1.86e-02	1.56e-09	7.33e-08
Reactome-AC4 Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.45e-03
Somatic Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.68e-03
Overlap	Exclusives	1.46e-16	6.87e-12	1.07e-120	2.96e-24



Evaluating how well Reactome-AC4 genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Reactome-AC4 Exclusive	Somatic	0.81	-4.51	0.11	-0.92	7.19
Somatic Exclusive	Reactome-AC4	0.57	-0.98	-2.80	-0.72	4.36
Reactome-AC4 Exclusive	Somatic Exclusive	0.79	-4.98	-0.18	-1.26	6.95
Somatic Exclusive	Reactome-AC4 Exclusive	0.56	-1.29	-2.93	-0.77	4.44
Reactome-AC4 Exclusive	Overlap	1.00	1.46	1.69	1.60	2.87
Somatic Exclusive	Overlap	1.00	1.14	2.79	1.90	3.02
Overlap	Exclusives	0.69	-0.17	6.09	1.40	12.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Reactome-AC4 Exclusive	Somatic	0.01	-2.63	3.63	-0.97	9.29
Somatic Exclusive	Reactome-AC4	0.02	-1.21	-1.32	0.32	4.55
Reactome-AC4 Exclusive	Somatic Exclusive	0.01	-2.53	-0.69	-1.56	9.21
Somatic Exclusive	Reactome-AC4 Exclusive	0.02	-1.34	-1.94	0.06	3.76
Reactome-AC4 Exclusive	Overlap	0.05	-0.62	60.09	0.88	140.88
Somatic Exclusive	Overlap	0.01	-0.46	39.77	21.21	11.78
Overlap	Exclusives	0.10	25.39	65.62	14.05	89.87

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Reactome-AC4 Exclusive	338	337	
Somatic Exclusive	37	37	
Overlap	3	3