Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-Somatic	AD-Final25	6.97e-01	4.69e-01	2.16e-04	6.22e-03
AD-Final25	BRCA-Somatic	2.95e-01	1.79e-01	1.16e-02	1.09e-07



Evaluating how well BRCA-Somatic genes are linked to AD-Final25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic	AD-Final25	0.69	0.19	1.28	0.85	3.68
AD-Final25	BRCA-Somatic	0.78	0.09	1.89	0.55	5.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic	AD-Final25	0.00	-0.58	0.31	0.08	2.42
AD-Final25	BRCA-Somatic	0.01	-0.04	-0.10	1.08	4.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-Somatic	40	40	
AD-Final25	25	25