Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-GWAS Exclusive	BRCA-Somatic	9.25e-12	1.25e-12	1.62e-22	7.61e-26
BRCA-Somatic Exclusive	BRCA-GWAS	1.45e-06	2.15e-05	2.29e-27	1.37e-15
BRCA-GWAS Exclusive	BRCA-Somatic Exclusive	2.20e-09	1.37e-10	9.45e-18	1.87e-21
BRCA-Somatic Exclusive	BRCA-GWAS Exclusive	5.21e-05	4.38e-05	1.14e-24	1.51e-13
BRCA-GWAS Exclusive	Overlap	2.03e-03	7.73e-04	3.92e-06	7.25e-06
BRCA-Somatic Exclusive	Overlap	2.74e-06	1.64e-04	2.62e-06	5.34e-06
Overlap	Exclusives	3.86e-09	1.53e-07	3.33e-29	2.89e-21



Evaluating how well BRCA-GWAS genes are linked to BRCA-Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-GWAS Exclusive	BRCA-Somatic	0.96	2.80	6.52	4.04	8.96
BRCA-Somatic Exclusive	BRCA-GWAS	0.70	4.02	4.81	4.61	9.07
BRCA-GWAS Exclusive	BRCA-Somatic Exclusive	0.96	2.30	5.51	3.67	8.19
BRCA-Somatic Exclusive	BRCA-GWAS Exclusive	0.68	4.31	4.64	4.23	8.06
BRCA-GWAS Exclusive	Overlap	0.99	2.03	2.99	2.88	4.47
BRCA-Somatic Exclusive	Overlap	0.99	2.65	2.57	3.05	3.84
Overlap	Exclusives	0.73	4.03	6.73	2.54	10.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-GWAS Exclusive	BRCA-Somatic	0.21	8.02	55.65	56.60	526.48
BRCA-Somatic Exclusive	BRCA-GWAS	0.04	3.68	13.39	22.18	25.92
BRCA-GWAS Exclusive	BRCA-Somatic Exclusive	0.20	7.46	63.05	60.34	432.13
BRCA-Somatic Exclusive	BRCA-GWAS Exclusive	0.03	3.00	7.45	11.94	20.21
BRCA-GWAS Exclusive	Overlap	0.02	4.85	27.00	19.00	9.94
BRCA-Somatic Exclusive	Overlap	0.03	7.14	59.01	76.77	93.44
Overlap	Exclusives	0.06	19.51	26.58	19.38	43.82

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-GWAS Exclusive	163	162	
BRCA-Somatic Exclusive	34	34	
Overlap	6	6