Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-GWAS Exclusive	Rare2MethodConsensus	5.29e-01	5.23e-02	1.31e-07	2.17e-06
Rare2MethodConsensus Exclusive	BRCA-GWAS	5.55e-01	7.64e-01	3.27e-03	8.33e-06
BRCA-GWAS Exclusive	Rare2MethodConsensus Exclusive	5.59e-01	6.49e-02	1.48e-07	2.02e-04
Rare2MethodConsensus Exclusive	BRCA-GWAS Exclusive	4.78e-01	8.08e-01	6.39e-03	6.76e-05
BRCA-GWAS Exclusive	Overlap	1.60e-02	1.04e-01	1.25e-04	5.79e-05
Rare2MethodConsensus Exclusive	Overlap	1.69e-01	1.66e-01	1.02e-02	1.79e-03
Overlap	Exclusives	8.32e-03	6.52e-03	2.21e-48	1.85e-09



Evaluating how well BRCA-GWAS genes are linked to Rare2MethodConsensus genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-GWAS Exclusive	Rare2MethodConsensus	0.61	1.20	1.51	1.52	5.28
Rare2MethodConsensus Exclusive	BRCA-GWAS	0.63	0.77	1.10	1.58	5.83
BRCA-GWAS Exclusive	Rare2MethodConsensus Exclusive	0.59	1.10	1.47	1.69	3.92
Rare2MethodConsensus Exclusive	BRCA-GWAS Exclusive	0.62	0.93	1.18	1.43	5.67
BRCA-GWAS Exclusive	Overlap	0.95	1.20	1.68	2.04	4.38
Rare2MethodConsensus Exclusive	Overlap	0.87	0.10	0.62	0.89	3.59
Overlap	Exclusives	0.63	2.48	3.38	2.12	8.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-GWAS Exclusive	Rare2MethodConsensus	0.02	4.22	10.29	10.40	19.63
Rare2MethodConsensus Exclusive	BRCA-GWAS	0.02	0.29	2.39	2.72	10.66
BRCA-GWAS Exclusive	Rare2MethodConsensus Exclusive	0.02	2.79	11.67	9.71	16.25
Rare2MethodConsensus Exclusive	BRCA-GWAS Exclusive	0.01	0.05	1.09	1.77	7.84
BRCA-GWAS Exclusive	Overlap	0.02	2.40	2.49	11.90	72.49
Rare2MethodConsensus Exclusive	Overlap	0.01	3.51	20.30	9.59	22.79
Overlap	Exclusives	0.03	4.79	9.56	7.62	14.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-GWAS Exclusive	160	160	
Rare2MethodConsensus Exclusive	142	140	SSPO;C4B_2
Overlap	9	8