Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD-Final25	BRCA-Familial	1.32e-02	5.28e-01	2.50e-02	7.71e-04
BRCA-Familial	AD-Final25	6.91e-01	7.61e-01	1.02e-03	2.03e-02



Evaluating how well AD-Final25 genes are linked to BRCA-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD-Final25	BRCA-Familial	0.71	-1.02	-0.98	-0.33	4.09
BRCA-Familial	AD-Final25	0.66	0.50	0.71	0.74	2.78

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD-Final25	BRCA-Familial	0.00	-0.62	-0.23	0.08	1.92
BRCA-Familial	AD-Final25	0.00	-0.26	-0.34	0.24	-0.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD-Final25	25	25	
BRCA-Familial	31	31