Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Rare2MethodGenes Exclusive	BRCA-Somatic	7.12e-01	2.75e-01	6.31e-05	1.08e-13
BRCA-Somatic Exclusive	Rare2MethodGenes	1.94e-02	4.94e-01	1.02e-08	1.97e-04
Rare2MethodGenes Exclusive	BRCA-Somatic Exclusive	9.58e-01	2.39e-01	1.19e-04	1.13e-12
BRCA-Somatic Exclusive	Rare2MethodGenes Exclusive	9.83e-03	3.91e-01	6.02e-09	5.79e-04
Rare2MethodGenes Exclusive	Overlap	1.06e-02	1.02e-02	1.02e-02	3.53e-04
BRCA-Somatic Exclusive	Overlap	1.69e-04	1.69e-04	1.69e-04	1.86e-04
Overlap	Exclusives	8.43e-12	1.63e-07	3.15e-46	3.68e-12



Evaluating how well Rare2MethodGenes genes are linked to BRCA-Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes Exclusive	BRCA-Somatic	0.87	0.06	1.92	1.75	7.72
BRCA-Somatic Exclusive	Rare2MethodGenes	0.61	1.07	1.17	1.65	4.57
Rare2MethodGenes Exclusive	BRCA-Somatic Exclusive	0.86	-0.00	2.43	1.69	6.95
BRCA-Somatic Exclusive	Rare2MethodGenes Exclusive	0.59	0.65	1.04	1.83	4.27
Rare2MethodGenes Exclusive	Overlap	0.99	1.20	1.73	1.69	3.64
BRCA-Somatic Exclusive	Overlap	1.00	1.25	2.92	2.14	3.13
Overlap	Exclusives	0.68	2.64	4.02	2.18	7.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes Exclusive	BRCA-Somatic	0.02	-0.81	5.53	2.49	5.93
BRCA-Somatic Exclusive	Rare2MethodGenes	0.01	-0.20	2.40	3.74	7.42
Rare2MethodGenes Exclusive	BRCA-Somatic Exclusive	0.01	-1.04	1.09	0.84	9.39
BRCA-Somatic Exclusive	Rare2MethodGenes Exclusive	0.01	-0.37	0.20	2.13	1.68
Rare2MethodGenes Exclusive	Overlap	0.05	1.00	61.26	8.91	219.10
BRCA-Somatic Exclusive	Overlap	0.05	-0.10	115.98	59.63	118.11
Overlap	Exclusives	0.03	30.42	19.22	9.89	31.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Rare2MethodGenes Exclusive	147	144	;C4B_2;SSPO
BRCA-Somatic Exclusive	36	36	
Overlap	4	4