Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Rare2MethodGenes	AD-Final25	1.98e-01	4.34e-02	2.74e-03	1.69e-04
AD-Final25	Rare2MethodGenes	1.18e-03	6.01e-01	4.76e-02	2.13e-02



Evaluating how well Rare2MethodGenes genes are linked to AD-Final25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes	AD-Final25	0.73	1.43	2.54	1.58	3.92
AD-Final25	Rare2MethodGenes	0.57	-0.24	0.69	0.22	3.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes	AD-Final25	0.00	0.25	0.36	0.92	2.38
AD-Final25	Rare2MethodGenes	0.01	0.73	2.21	1.80	4.14

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Rare2MethodGenes	151	148	;SSPO;C4B_2
AD-Final25	25	25