Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	EPI-AF1	1.15e-04	7.78e-01	4.14e-02	7.66e-01
EPI-AF1 Exclusive	Viral	5.42e-05	6.46e-05	5.69e-04	4.01e-15
Viral Exclusive	EPI-AF1 Exclusive	1.44e-04	8.42e-01	4.88e-02	8.44e-01
EPI-AF1 Exclusive	Viral Exclusive	2.42e-04	5.92e-05	4.71e-06	2.01e-14
Viral Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.57e-01
EPI-AF1 Exclusive	Overlap	7.73e-01	2.06e-01	5.50e-01	4.53e-01
Overlap	Exclusives	1.30e-15	7.65e-05	1.37e-30	9.23e-15



Evaluating how well Viral genes are linked to EPI-AF1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	EPI-AF1	0.52	1.27	0.63	0.42	0.75
EPI-AF1 Exclusive	Viral	0.74	1.90	6.22	1.71	8.98
Viral Exclusive	EPI-AF1 Exclusive	0.52	1.15	0.35	0.61	0.56
EPI-AF1 Exclusive	Viral Exclusive	0.74	1.62	5.55	2.35	9.21
Viral Exclusive	Overlap	0.96	0.46	2.43	1.59	1.52
EPI-AF1 Exclusive	Overlap	0.63	0.02	-0.82	-0.36	0.54
Overlap	Exclusives	0.68	3.61	4.86	1.91	8.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	EPI-AF1	0.01	2.16	1.18	1.05	1.51
EPI-AF1 Exclusive	Viral	0.01	1.42	7.06	1.00	4.38
Viral Exclusive	EPI-AF1 Exclusive	0.01	2.63	0.82	0.53	1.11
EPI-AF1 Exclusive	Viral Exclusive	0.01	1.17	6.34	2.65	4.61
Viral Exclusive	Overlap	0.00	-0.22	16.24	2.57	1.11
EPI-AF1 Exclusive	Overlap	0.00	-0.32	-0.55	-0.46	-0.15
Overlap	Exclusives	0.02	8.30	3.77	1.32	11.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	123	110	SRY;HLA-Cw;UNC93B;SNORA31;HLA-DRB4;MBL3P;IFNL4;TNFα;HLA-DRB3;Mig;IL12;FCER;HLA
EPI-AF1 Exclusive	88	86	POC1B-GALNT4;C1GALT1C1L
Overlap	1	1