Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Rare2MethodGenes	AD-Final25	2.42e-01	5.86e-02	4.97e-03	2.28e-04
AD-Final25	Rare2MethodGenes	6.45e-04	6.39e-01	8.55e-02	5.39e-02



Evaluating how well Rare2MethodGenes genes are linked to AD-Final25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes	AD-Final25	0.73	1.55	2.49	1.49	4.54
AD-Final25	Rare2MethodGenes	0.57	-0.45	0.46	-0.15	3.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes	AD-Final25	0.00	0.56	0.65	0.66	1.45
AD-Final25	Rare2MethodGenes	0.01	0.82	2.01	1.71	4.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Rare2MethodGenes	154	150	;undefined;C4B_2;SSPO
AD-Final25	25	25