Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Rare2MethodGenes Exclusive	MI-Pathogenic	1.04e-02	1.54e-04	3.23e-07	1.55e-10
MI-Pathogenic Exclusive	Rare2MethodGenes	3.67e-04	3.98e-04	4.04e-09	6.07e-07
Rare2MethodGenes Exclusive	MI-Pathogenic Exclusive	7.93e-03	1.04e-04	1.16e-06	1.23e-08
MI-Pathogenic Exclusive	Rare2MethodGenes Exclusive	6.37e-04	1.27e-03	8.43e-08	2.43e-06
Rare2MethodGenes Exclusive	Overlap	2.33e-01	1.78e-01	2.48e-02	5.28e-03
MI-Pathogenic Exclusive	Overlap	3.70e-03	4.63e-03	1.53e-03	4.23e-03
Overlap	Exclusives	2.92e-04	5.68e-05	1.15e-32	2.54e-08



Evaluating how well Rare2MethodGenes genes are linked to MI-Pathogenic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes Exclusive	MI-Pathogenic	0.80	1.80	4.11	2.13	6.47
MI-Pathogenic Exclusive	Rare2MethodGenes	0.65	4.28	4.49	3.63	5.66
Rare2MethodGenes Exclusive	MI-Pathogenic Exclusive	0.79	2.02	4.61	2.52	6.15
MI-Pathogenic Exclusive	Rare2MethodGenes Exclusive	0.64	4.31	4.38	3.32	6.12
Rare2MethodGenes Exclusive	Overlap	0.92	0.65	0.91	1.01	2.42
MI-Pathogenic Exclusive	Overlap	0.98	1.81	2.76	2.44	2.80
Overlap	Exclusives	0.65	2.59	4.34	1.84	7.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Rare2MethodGenes Exclusive	MI-Pathogenic	0.01	2.56	6.24	3.61	6.42
MI-Pathogenic Exclusive	Rare2MethodGenes	0.01	4.30	5.98	4.76	8.96
Rare2MethodGenes Exclusive	MI-Pathogenic Exclusive	0.01	2.98	7.32	4.89	6.87
MI-Pathogenic Exclusive	Rare2MethodGenes Exclusive	0.01	3.08	4.24	4.07	4.35
Rare2MethodGenes Exclusive	Overlap	0.00	-0.26	1.47	-0.05	0.05
MI-Pathogenic Exclusive	Overlap	0.04	22.23	109.84	126.02	32.46
Overlap	Exclusives	0.02	8.90	10.80	4.52	16.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Rare2MethodGenes Exclusive	154	151	;C4B_2;SSPO
MI-Pathogenic Exclusive	36	36	
Overlap	3	3