Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD-Final25	BRCA-Familial	2.73e-04	2.81e-03	4.80e-02	4.12e-02
BRCA-Familial	AD-Final25	4.37e-03	7.94e-01	1.40e-01	8.76e-02



Evaluating how well AD-Final25 genes are linked to BRCA-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD-Final25	BRCA-Familial	0.62	-1.36	-3.76	-1.35	1.74
BRCA-Familial	AD-Final25	0.60	-1.49	-1.15	-0.41	1.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD-Final25	BRCA-Familial	0.00	-0.83	-2.24	-0.62	0.24
BRCA-Familial	AD-Final25	0.00	-1.28	-0.87	-0.55	0.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD-Final25	25	25	
BRCA-Familial	23	23