Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD-Final25	BRCA-GWAS	1.26e-01	7.40e-01	3.89e-02	3.29e-06
BRCA-GWAS	AD-Final25	7.25e-01	7.08e-01	1.27e-02	1.00e-02



Evaluating how well AD-Final25 genes are linked to BRCA-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD-Final25	BRCA-GWAS	0.61	0.41	0.54	0.34	5.08
BRCA-GWAS	AD-Final25	0.69	-0.32	1.33	1.01	3.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD-Final25	BRCA-GWAS	0.01	-0.07	-0.80	0.31	2.05
BRCA-GWAS	AD-Final25	0.00	-0.91	0.62	0.20	2.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD-Final25	25	25	
BRCA-GWAS	173	172