Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD-Final25	BRCA-Somatic	2.62e-01	1.01e-01	1.15e-02	5.32e-08
BRCA-Somatic	AD-Final25	8.42e-01	3.01e-01	6.09e-05	4.56e-03



Evaluating how well AD-Final25 genes are linked to BRCA-Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD-Final25	BRCA-Somatic	0.79	0.32	3.04	0.52	6.14
BRCA-Somatic	AD-Final25	0.70	0.60	1.82	0.97	3.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD-Final25	BRCA-Somatic	0.01	0.08	0.79	0.74	6.43
BRCA-Somatic	AD-Final25	0.00	-0.34	0.39	0.25	1.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD-Final25	25	25	
BRCA-Somatic	37	37