Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD-Final25	Rare2MethodConsensus	2.92e-03	4.63e-01	6.22e-02	5.39e-02
Rare2MethodConsensus	AD-Final25	1.86e-02	2.06e-03	9.49e-05	8.66e-06



Evaluating how well AD-Final25 genes are linked to Rare2MethodConsensus genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD-Final25	Rare2MethodConsensus	0.57	-0.21	0.76	0.17	2.66
Rare2MethodConsensus	AD-Final25	0.74	2.16	3.17	1.79	4.49

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD-Final25	Rare2MethodConsensus	0.01	0.96	2.51	1.59	3.93
Rare2MethodConsensus	AD-Final25	0.00	0.98	0.48	0.92	3.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD-Final25	25	25	
Rare2MethodConsensus	157	154	;C4B_2;SSPO