Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD-Final25	MI-Pathogenic	1.65e-08	1.51e-06	1.24e-10	7.86e-12
MI-Pathogenic	AD-Final25	3.81e-04	1.49e-05	4.33e-09	3.71e-07



Evaluating how well AD-Final25 genes are linked to MI-Pathogenic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD-Final25	MI-Pathogenic	0.85	3.08	5.63	3.72	8.03
MI-Pathogenic	AD-Final25	0.79	2.93	3.98	3.17	4.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD-Final25	MI-Pathogenic	0.02	8.96	30.41	17.62	6.11
MI-Pathogenic	AD-Final25	0.01	5.23	11.31	18.93	14.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD-Final25	25	25	
MI-Pathogenic	39	39