Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-Familial Exclusive	All-Familial	1.67e-19	2.60e-21	1.50e-30	3.09e-31
All-Familial Exclusive	BRCA-Familial	3.44e-21	3.05e-17	2.08e-21	7.58e-21
BRCA-Familial Exclusive	All-Familial Exclusive	7.95e-11	1.54e-12	2.15e-21	1.36e-20
All-Familial Exclusive	BRCA-Familial Exclusive	3.30e-07	2.24e-05	3.30e-07	5.86e-07
BRCA-Familial Exclusive	Overlap	1.17e-14	3.90e-14	3.46e-15	7.09e-15
All-Familial Exclusive	Overlap	3.17e-15	3.05e-14	3.17e-15	5.51e-15
Overlap	Exclusives	2.64e-21	4.99e-16	3.01e-28	7.91e-25



Evaluating how well BRCA-Familial genes are linked to All-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Familial Exclusive	All-Familial	0.94	3.50	11.14	3.68	11.55
All-Familial Exclusive	BRCA-Familial	1.00	2.96	5.82	2.93	7.39
BRCA-Familial Exclusive	All-Familial Exclusive	0.91	4.02	7.57	4.02	10.66
All-Familial Exclusive	BRCA-Familial Exclusive	0.99	2.46	3.15	3.83	4.18
BRCA-Familial Exclusive	Overlap	1.00	2.32	7.04	2.96	6.49
All-Familial Exclusive	Overlap	1.00	2.97	7.03	3.39	6.47
Overlap	Exclusives	0.92	3.17	8.55	4.37	10.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Familial Exclusive	All-Familial	0.13	15.07	156.45	74.02	350.73
All-Familial Exclusive	BRCA-Familial	0.27	26.93	236.94	117.48	607.84
BRCA-Familial Exclusive	All-Familial Exclusive	0.04	10.55	54.55	27.12	76.84
All-Familial Exclusive	BRCA-Familial Exclusive	0.05	18.86	71.15	182.60	123.60
BRCA-Familial Exclusive	Overlap	0.17	21.92	307.49	138.62	328.78
All-Familial Exclusive	Overlap	0.24	14.21	316.86	225.24	854.34
Overlap	Exclusives	0.09	26.02	97.87	57.88	30.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-Familial Exclusive	7	7	
All-Familial Exclusive	44	44	
Overlap	16	16