Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-Familial	MI-Pathogenic	1.10e-02	9.64e-01	3.18e-04	7.50e-05
MI-Pathogenic	BRCA-Familial	2.39e-05	1.00e-05	8.80e-14	2.44e-15



Evaluating how well BRCA-Familial genes are linked to MI-Pathogenic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Familial	MI-Pathogenic	0.70	-0.45	0.12	0.72	4.25
MI-Pathogenic	BRCA-Familial	0.91	1.78	4.30	2.06	6.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Familial	MI-Pathogenic	0.01	-0.12	1.85	2.14	1.19
MI-Pathogenic	BRCA-Familial	0.01	-0.26	3.96	1.86	8.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-Familial	23	23	
MI-Pathogenic	39	39