Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-GWAS	AD-Final25	6.01e-01	7.94e-01	9.25e-03	9.12e-03
AD-Final25	BRCA-GWAS	1.46e-01	7.78e-01	6.86e-02	4.30e-06



Evaluating how well BRCA-GWAS genes are linked to AD-Final25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-GWAS	AD-Final25	0.69	-0.63	1.09	0.97	3.06
AD-Final25	BRCA-GWAS	0.61	0.38	0.34	0.61	4.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-GWAS	AD-Final25	0.00	-1.09	0.65	0.32	1.27
AD-Final25	BRCA-GWAS	0.01	-0.16	-0.81	0.54	2.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-GWAS	173	172	
AD-Final25	25	25