Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-GWAS Exclusive	BRCA-Somatic	1.87e-09	4.52e-12	1.67e-19	7.47e-23
BRCA-Somatic Exclusive	BRCA-GWAS	2.97e-06	2.99e-06	2.80e-28	3.50e-16
BRCA-GWAS Exclusive	BRCA-Somatic Exclusive	1.98e-07	2.81e-09	4.08e-15	2.45e-18
BRCA-Somatic Exclusive	BRCA-GWAS Exclusive	4.05e-05	1.23e-05	4.50e-26	1.07e-13
BRCA-GWAS Exclusive	Overlap	3.15e-03	3.16e-04	7.62e-07	8.30e-07
BRCA-Somatic Exclusive	Overlap	3.61e-07	1.22e-06	3.30e-07	6.12e-07
Overlap	Exclusives	1.54e-10	3.59e-07	1.03e-31	3.50e-19



Evaluating how well BRCA-GWAS genes are linked to BRCA-Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-GWAS Exclusive	BRCA-Somatic	0.96	2.27	7.46	3.48	9.76
BRCA-Somatic Exclusive	BRCA-GWAS	0.69	4.10	4.79	3.74	7.81
BRCA-GWAS Exclusive	BRCA-Somatic Exclusive	0.96	2.64	4.52	3.12	10.17
BRCA-Somatic Exclusive	BRCA-GWAS Exclusive	0.67	4.17	4.76	3.52	8.28
BRCA-GWAS Exclusive	Overlap	0.99	1.88	4.25	2.78	4.09
BRCA-Somatic Exclusive	Overlap	0.99	2.51	3.43	3.10	5.00
Overlap	Exclusives	0.72	4.05	5.82	3.22	10.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-GWAS Exclusive	BRCA-Somatic	0.23	6.99	68.50	51.34	448.97
BRCA-Somatic Exclusive	BRCA-GWAS	0.03	3.86	12.86	20.00	30.30
BRCA-GWAS Exclusive	BRCA-Somatic Exclusive	0.19	5.40	52.66	39.18	308.33
BRCA-Somatic Exclusive	BRCA-GWAS Exclusive	0.03	4.63	7.99	13.56	27.45
BRCA-GWAS Exclusive	Overlap	0.05	5.25	86.84	42.77	138.52
BRCA-Somatic Exclusive	Overlap	0.03	1.42	57.60	71.69	25.79
Overlap	Exclusives	0.06	14.53	28.55	26.18	42.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-GWAS Exclusive	166	165	
BRCA-Somatic Exclusive	30	30	
Overlap	7	7