Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-GWAS Exclusive	Rare2MethodConsensus	6.31e-01	5.44e-02	1.02e-07	1.15e-05
Rare2MethodConsensus Exclusive	BRCA-GWAS	4.43e-01	7.50e-01	1.29e-03	6.49e-06
BRCA-GWAS Exclusive	Rare2MethodConsensus Exclusive	6.89e-01	5.69e-02	1.09e-06	3.12e-04
Rare2MethodConsensus Exclusive	BRCA-GWAS Exclusive	4.00e-01	5.47e-01	5.06e-03	7.10e-05
BRCA-GWAS Exclusive	Overlap	1.05e-02	1.04e-01	1.02e-04	1.42e-04
Rare2MethodConsensus Exclusive	Overlap	1.66e-01	1.66e-01	2.06e-02	3.01e-03
Overlap	Exclusives	1.09e-02	5.98e-03	1.45e-49	1.12e-09



Evaluating how well BRCA-GWAS genes are linked to Rare2MethodConsensus genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-GWAS Exclusive	Rare2MethodConsensus	0.61	1.08	1.69	1.69	4.72
Rare2MethodConsensus Exclusive	BRCA-GWAS	0.63	0.85	1.07	1.78	5.45
BRCA-GWAS Exclusive	Rare2MethodConsensus Exclusive	0.59	0.97	1.57	1.29	3.47
Rare2MethodConsensus Exclusive	BRCA-GWAS Exclusive	0.61	0.93	1.37	1.16	5.01
BRCA-GWAS Exclusive	Overlap	0.94	1.30	1.69	2.28	4.06
Rare2MethodConsensus Exclusive	Overlap	0.86	-0.04	0.54	0.68	3.40
Overlap	Exclusives	0.63	2.33	3.46	2.46	7.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-GWAS Exclusive	Rare2MethodConsensus	0.02	3.85	9.10	9.47	17.02
Rare2MethodConsensus Exclusive	BRCA-GWAS	0.02	0.56	2.61	3.16	5.44
BRCA-GWAS Exclusive	Rare2MethodConsensus Exclusive	0.02	3.20	13.72	8.61	11.63
Rare2MethodConsensus Exclusive	BRCA-GWAS Exclusive	0.01	-0.11	0.94	1.32	4.64
BRCA-GWAS Exclusive	Overlap	0.02	3.76	1.65	19.57	6.15
Rare2MethodConsensus Exclusive	Overlap	0.02	5.26	21.73	11.67	35.34
Overlap	Exclusives	0.03	4.81	10.61	8.70	12.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-GWAS Exclusive	164	164	
Rare2MethodConsensus Exclusive	148	146	SSPO;C4B_2
Overlap	9	8