Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-GWAS	MI-Pathogenic	5.11e-01	9.90e-01	1.66e-04	3.77e-05
MI-Pathogenic	BRCA-GWAS	4.75e-02	4.40e-02	1.84e-06	1.90e-06



Evaluating how well BRCA-GWAS genes are linked to MI-Pathogenic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-GWAS	MI-Pathogenic	0.72	-0.68	0.12	0.70	4.82
MI-Pathogenic	BRCA-GWAS	0.62	-0.32	1.32	1.27	5.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-GWAS	MI-Pathogenic	0.01	-0.49	0.25	0.98	7.58
MI-Pathogenic	BRCA-GWAS	0.01	-1.09	0.56	1.50	3.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-GWAS	173	172	
MI-Pathogenic	39	39