Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-Somatic	AD-Final25	7.38e-01	2.80e-01	3.32e-05	5.88e-03
AD-Final25	BRCA-Somatic	2.57e-01	1.62e-01	6.25e-03	6.23e-08



Evaluating how well BRCA-Somatic genes are linked to AD-Final25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic	AD-Final25	0.70	0.92	1.64	1.05	3.66
AD-Final25	BRCA-Somatic	0.79	0.33	2.14	0.69	6.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic	AD-Final25	0.00	-0.21	0.65	0.55	2.32
AD-Final25	BRCA-Somatic	0.01	0.13	0.44	1.09	7.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-Somatic	37	37	
AD-Final25	25	25