Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-Somatic Exclusive	All-Familial	2.17e-08	1.55e-05	1.36e-24	2.99e-19
All-Familial Exclusive	BRCA-Somatic	2.59e-08	2.26e-07	4.30e-20	1.64e-20
BRCA-Somatic Exclusive	All-Familial Exclusive	1.51e-05	6.09e-06	3.51e-21	4.02e-17
All-Familial Exclusive	BRCA-Somatic Exclusive	7.54e-06	1.90e-04	1.52e-15	8.66e-16
BRCA-Somatic Exclusive	Overlap	3.30e-07	9.94e-06	3.30e-07	3.77e-07
All-Familial Exclusive	Overlap	2.08e-05	2.08e-05	3.45e-07	4.92e-07
Overlap	Exclusives	3.79e-30	9.89e-26	2.61e-50	2.83e-42



Evaluating how well BRCA-Somatic genes are linked to All-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic Exclusive	All-Familial	0.87	1.96	5.45	2.96	9.94
All-Familial Exclusive	BRCA-Somatic	0.93	1.11	4.99	3.62	9.41
BRCA-Somatic Exclusive	All-Familial Exclusive	0.86	1.98	6.10	3.22	8.76
All-Familial Exclusive	BRCA-Somatic Exclusive	0.92	1.05	3.82	2.90	7.63
BRCA-Somatic Exclusive	Overlap	1.00	1.77	2.13	2.57	3.99
All-Familial Exclusive	Overlap	0.99	1.24	4.32	2.74	4.80
Overlap	Exclusives	0.93	6.21	10.75	3.60	14.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic Exclusive	All-Familial	0.03	1.11	10.39	11.63	47.42
All-Familial Exclusive	BRCA-Somatic	0.03	-0.69	16.07	15.31	58.72
BRCA-Somatic Exclusive	All-Familial Exclusive	0.02	0.47	7.76	8.42	19.76
All-Familial Exclusive	BRCA-Somatic Exclusive	0.02	-0.53	8.80	9.94	4.25
BRCA-Somatic Exclusive	Overlap	0.04	1.19	18.97	37.46	112.81
All-Familial Exclusive	Overlap	0.03	-0.31	53.80	25.21	98.63
Overlap	Exclusives	0.13	30.31	107.14	49.79	259.40

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-Somatic Exclusive	30	30	
All-Familial Exclusive	53	53	
Overlap	7	7