Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-Somatic Exclusive	BRCA-Familial	2.29e-08	2.65e-05	4.96e-14	1.38e-12
BRCA-Familial Exclusive	BRCA-Somatic	5.36e-07	1.23e-06	6.83e-16	2.58e-20
BRCA-Somatic Exclusive	BRCA-Familial Exclusive	1.85e-04	7.96e-03	4.61e-11	1.83e-08
BRCA-Familial Exclusive	BRCA-Somatic Exclusive	1.48e-04	5.11e-05	8.45e-12	3.52e-17
BRCA-Somatic Exclusive	Overlap	2.62e-06	7.05e-05	2.62e-06	4.10e-06
BRCA-Familial Exclusive	Overlap	1.64e-04	4.94e-05	2.62e-06	4.68e-06
Overlap	Exclusives	1.08e-26	3.86e-22	1.96e-32	3.99e-28



Evaluating how well BRCA-Somatic genes are linked to BRCA-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic Exclusive	BRCA-Familial	0.94	1.23	4.69	2.28	7.60
BRCA-Familial Exclusive	BRCA-Somatic	0.94	2.35	6.09	3.50	9.26
BRCA-Somatic Exclusive	BRCA-Familial Exclusive	0.92	1.00	4.05	2.09	5.64
BRCA-Familial Exclusive	BRCA-Somatic Exclusive	0.93	2.13	5.00	3.78	8.26
BRCA-Somatic Exclusive	Overlap	0.99	1.59	2.53	2.52	4.59
BRCA-Familial Exclusive	Overlap	0.99	1.38	4.17	2.63	4.11
Overlap	Exclusives	0.96	4.90	9.35	3.22	11.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic Exclusive	BRCA-Familial	0.03	0.10	17.52	12.81	21.00
BRCA-Familial Exclusive	BRCA-Somatic	0.02	0.78	14.39	11.98	22.68
BRCA-Somatic Exclusive	BRCA-Familial Exclusive	0.01	-0.20	6.94	5.95	20.97
BRCA-Familial Exclusive	BRCA-Somatic Exclusive	0.01	0.32	8.46	9.80	27.55
BRCA-Somatic Exclusive	Overlap	0.03	0.32	11.24	43.52	72.39
BRCA-Familial Exclusive	Overlap	0.01	0.83	53.16	22.35	8.77
Overlap	Exclusives	0.13	27.32	133.40	63.42	237.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-Somatic Exclusive	31	31	
BRCA-Familial Exclusive	17	17	
Overlap	6	6