Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-Somatic Exclusive	BRCA-GWAS	2.11e-06	4.99e-06	1.98e-28	3.55e-16
BRCA-GWAS Exclusive	BRCA-Somatic	1.75e-09	2.17e-12	8.64e-20	2.33e-23
BRCA-Somatic Exclusive	BRCA-GWAS Exclusive	4.20e-05	6.04e-06	1.17e-26	1.43e-14
BRCA-GWAS Exclusive	BRCA-Somatic Exclusive	1.26e-07	2.96e-09	4.21e-15	8.82e-19
BRCA-Somatic Exclusive	Overlap	4.31e-07	8.30e-07	3.30e-07	6.12e-07
BRCA-GWAS Exclusive	Overlap	1.70e-03	2.34e-04	7.95e-07	1.08e-06
Overlap	Exclusives	5.12e-10	1.12e-06	1.57e-28	5.59e-19



Evaluating how well BRCA-Somatic genes are linked to BRCA-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic Exclusive	BRCA-GWAS	0.69	4.85	4.79	4.05	7.91
BRCA-GWAS Exclusive	BRCA-Somatic	0.96	2.64	5.69	3.51	10.07
BRCA-Somatic Exclusive	BRCA-GWAS Exclusive	0.67	4.01	4.58	3.77	7.33
BRCA-GWAS Exclusive	BRCA-Somatic Exclusive	0.96	2.56	4.75	3.67	9.07
BRCA-Somatic Exclusive	Overlap	0.99	2.79	3.06	3.60	4.79
BRCA-GWAS Exclusive	Overlap	0.99	2.09	3.95	2.76	4.52
Overlap	Exclusives	0.72	4.65	5.51	3.03	10.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic Exclusive	BRCA-GWAS	0.03	4.61	9.47	19.34	23.35
BRCA-GWAS Exclusive	BRCA-Somatic	0.23	7.16	65.53	45.04	507.88
BRCA-Somatic Exclusive	BRCA-GWAS Exclusive	0.03	3.39	6.22	12.41	10.50
BRCA-GWAS Exclusive	BRCA-Somatic Exclusive	0.19	6.43	61.39	42.63	521.48
BRCA-Somatic Exclusive	Overlap	0.03	2.54	48.22	91.23	23.51
BRCA-GWAS Exclusive	Overlap	0.05	7.92	97.02	37.85	85.76
Overlap	Exclusives	0.06	16.38	31.13	21.54	44.91

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-Somatic Exclusive	30	30	
BRCA-GWAS Exclusive	166	165	
Overlap	7	7