Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-Somatic Exclusive	Rare2MethodConsensus	1.54e-01	4.36e-02	4.18e-12	3.18e-06
Rare2MethodConsensus Exclusive	BRCA-Somatic	2.55e-01	4.09e-02	6.47e-04	3.28e-13
BRCA-Somatic Exclusive	Rare2MethodConsensus Exclusive	1.74e-01	3.31e-02	1.66e-11	1.04e-05
Rare2MethodConsensus Exclusive	BRCA-Somatic Exclusive	5.85e-01	1.83e-01	3.26e-04	5.66e-12
BRCA-Somatic Exclusive	Overlap	1.69e-04	3.86e-04	1.69e-04	1.77e-04
Rare2MethodConsensus Exclusive	Overlap	1.02e-02	1.02e-02	1.02e-02	3.37e-04
Overlap	Exclusives	1.40e-10	6.45e-08	1.20e-43	2.03e-11



Evaluating how well BRCA-Somatic genes are linked to Rare2MethodConsensus genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic Exclusive	Rare2MethodConsensus	0.62	2.46	2.55	2.45	5.45
Rare2MethodConsensus Exclusive	BRCA-Somatic	0.89	0.58	2.91	1.82	9.17
BRCA-Somatic Exclusive	Rare2MethodConsensus Exclusive	0.61	2.26	2.74	2.29	5.02
Rare2MethodConsensus Exclusive	BRCA-Somatic Exclusive	0.88	0.74	3.04	1.97	8.52
BRCA-Somatic Exclusive	Overlap	1.00	1.35	2.33	2.25	3.21
Rare2MethodConsensus Exclusive	Overlap	0.99	1.03	1.67	1.51	3.53
Overlap	Exclusives	0.67	1.51	3.88	2.21	7.95

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic Exclusive	Rare2MethodConsensus	0.01	0.03	3.12	4.40	4.73
Rare2MethodConsensus Exclusive	BRCA-Somatic	0.02	-0.68	9.94	1.90	54.43
BRCA-Somatic Exclusive	Rare2MethodConsensus Exclusive	0.01	0.13	0.81	2.18	2.73
Rare2MethodConsensus Exclusive	BRCA-Somatic Exclusive	0.01	-1.01	3.41	1.00	2.71
BRCA-Somatic Exclusive	Overlap	0.03	0.07	30.71	62.14	122.62
Rare2MethodConsensus Exclusive	Overlap	0.05	0.54	59.06	10.22	234.85
Overlap	Exclusives	0.03	12.59	18.27	10.90	13.97

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-Somatic Exclusive	33	33	
Rare2MethodConsensus Exclusive	153	150	;C4B_2;SSPO
Overlap	4	4