Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-Somatic	MI-Pathogenic	4.58e-01	1.41e-01	7.38e-07	6.29e-07
MI-Pathogenic	BRCA-Somatic	1.42e-01	2.03e-01	5.54e-05	1.32e-08



Evaluating how well BRCA-Somatic genes are linked to MI-Pathogenic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic	MI-Pathogenic	0.73	0.09	1.07	1.35	5.10
MI-Pathogenic	BRCA-Somatic	0.81	-0.83	1.50	1.07	6.38

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic	MI-Pathogenic	0.00	-0.54	-0.22	1.17	4.32
MI-Pathogenic	BRCA-Somatic	0.01	-1.19	1.32	1.27	4.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-Somatic	37	37	
MI-Pathogenic	39	39