Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
All-Familial Exclusive	BRCA-Familial	2.91e-21	3.82e-17	2.08e-21	9.32e-21
BRCA-Familial Exclusive	All-Familial	3.69e-20	2.53e-21	4.22e-31	1.00e-30
All-Familial Exclusive	BRCA-Familial Exclusive	3.45e-07	2.16e-05	3.30e-07	4.31e-07
BRCA-Familial Exclusive	All-Familial Exclusive	5.78e-11	1.51e-12	4.82e-21	1.49e-20
All-Familial Exclusive	Overlap	3.17e-15	3.17e-14	3.17e-15	6.25e-15
BRCA-Familial Exclusive	Overlap	2.80e-14	2.19e-14	3.46e-15	9.52e-15
Overlap	Exclusives	2.71e-21	4.11e-16	5.41e-29	8.65e-25



Evaluating how well All-Familial genes are linked to BRCA-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All-Familial Exclusive	BRCA-Familial	1.00	2.68	5.63	2.90	8.75
BRCA-Familial Exclusive	All-Familial	0.94	4.03	9.99	3.49	14.41
All-Familial Exclusive	BRCA-Familial Exclusive	0.99	2.51	2.81	2.76	4.51
BRCA-Familial Exclusive	All-Familial Exclusive	0.91	4.22	8.12	3.97	8.76
All-Familial Exclusive	Overlap	1.00	2.87	5.61	2.79	7.23
BRCA-Familial Exclusive	Overlap	1.00	2.42	7.31	2.84	6.37
Overlap	Exclusives	0.92	3.39	8.00	4.82	10.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All-Familial Exclusive	BRCA-Familial	0.27	23.39	187.70	94.07	865.94
BRCA-Familial Exclusive	All-Familial	0.13	25.08	128.44	73.67	264.18
All-Familial Exclusive	BRCA-Familial Exclusive	0.05	3.43	63.56	90.96	77.77
BRCA-Familial Exclusive	All-Familial Exclusive	0.04	15.11	60.98	34.10	78.36
All-Familial Exclusive	Overlap	0.24	19.72	326.19	132.03	120.58
BRCA-Familial Exclusive	Overlap	0.17	19.10	373.38	120.57	392.32
Overlap	Exclusives	0.09	24.05	85.55	96.68	40.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
All-Familial Exclusive	44	44	
BRCA-Familial Exclusive	7	7	
Overlap	16	16