Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
All-Familial Exclusive	BRCA-Somatic	1.69e-08	4.44e-07	4.58e-20	8.08e-21
BRCA-Somatic Exclusive	All-Familial	2.27e-08	1.38e-05	1.46e-23	1.50e-20
All-Familial Exclusive	BRCA-Somatic Exclusive	3.75e-06	2.22e-04	1.89e-15	6.13e-16
BRCA-Somatic Exclusive	All-Familial Exclusive	2.65e-05	3.93e-06	8.67e-22	1.09e-17
All-Familial Exclusive	Overlap	2.08e-05	2.08e-05	3.45e-07	6.98e-07
BRCA-Somatic Exclusive	Overlap	3.30e-07	1.03e-05	3.30e-07	3.45e-07
Overlap	Exclusives	2.91e-31	2.02e-25	9.50e-51	2.83e-42



Evaluating how well All-Familial genes are linked to BRCA-Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All-Familial Exclusive	BRCA-Somatic	0.93	1.20	5.11	3.19	9.00
BRCA-Somatic Exclusive	All-Familial	0.87	2.08	6.64	2.99	10.58
All-Familial Exclusive	BRCA-Somatic Exclusive	0.92	1.04	4.04	2.98	7.72
BRCA-Somatic Exclusive	All-Familial Exclusive	0.86	1.90	5.36	2.83	9.25
All-Familial Exclusive	Overlap	0.99	1.17	4.11	2.31	4.47
BRCA-Somatic Exclusive	Overlap	1.00	1.91	2.40	2.92	5.03
Overlap	Exclusives	0.93	5.87	10.75	3.64	13.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All-Familial Exclusive	BRCA-Somatic	0.03	-0.72	19.61	12.33	40.97
BRCA-Somatic Exclusive	All-Familial	0.03	0.81	12.53	13.12	55.66
All-Familial Exclusive	BRCA-Somatic Exclusive	0.02	-0.56	7.62	9.55	29.09
BRCA-Somatic Exclusive	All-Familial Exclusive	0.02	0.32	7.33	7.76	31.35
All-Familial Exclusive	Overlap	0.03	-0.25	50.72	16.43	98.00
BRCA-Somatic Exclusive	Overlap	0.04	1.16	16.51	61.01	100.85
Overlap	Exclusives	0.13	32.65	111.29	50.29	213.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
All-Familial Exclusive	53	53	
BRCA-Somatic Exclusive	30	30	
Overlap	7	7