Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
All-Familial Exclusive	Rare2MethodConsensus	3.04e-03	6.03e-02	3.42e-07	3.00e-06
Rare2MethodConsensus Exclusive	All-Familial	4.08e-12	1.07e-10	2.79e-16	1.79e-20
All-Familial Exclusive	Rare2MethodConsensus Exclusive	3.41e-02	4.48e-02	4.34e-05	6.21e-05
Rare2MethodConsensus Exclusive	All-Familial Exclusive	5.60e-09	9.98e-09	4.15e-13	2.19e-15
All-Familial Exclusive	Overlap	4.18e-08	4.18e-08	4.18e-08	4.37e-08
Rare2MethodConsensus Exclusive	Overlap	4.02e-06	7.35e-06	7.74e-07	6.78e-08
Overlap	Exclusives	4.57e-11	2.35e-07	6.54e-31	8.12e-13



Evaluating how well All-Familial genes are linked to Rare2MethodConsensus genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All-Familial Exclusive	Rare2MethodConsensus	0.63	3.42	3.84	3.22	5.98
Rare2MethodConsensus Exclusive	All-Familial	0.88	3.19	7.05	3.44	10.38
All-Familial Exclusive	Rare2MethodConsensus Exclusive	0.61	2.81	2.68	2.75	4.14
Rare2MethodConsensus Exclusive	All-Familial Exclusive	0.86	2.80	6.42	3.27	8.67
All-Familial Exclusive	Overlap	1.00	2.10	3.63	2.18	5.25
Rare2MethodConsensus Exclusive	Overlap	1.00	2.01	4.33	2.24	5.35
Overlap	Exclusives	0.68	2.09	5.53	3.28	8.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All-Familial Exclusive	Rare2MethodConsensus	0.04	9.51	40.24	34.73	49.27
Rare2MethodConsensus Exclusive	All-Familial	0.06	8.75	48.85	21.05	133.29
All-Familial Exclusive	Rare2MethodConsensus Exclusive	0.02	11.03	18.57	18.49	21.52
Rare2MethodConsensus Exclusive	All-Familial Exclusive	0.03	8.76	32.87	14.80	60.67
All-Familial Exclusive	Overlap	0.11	4.39	199.77	60.21	299.57
Rare2MethodConsensus Exclusive	Overlap	0.08	4.97	44.82	22.09	222.87
Overlap	Exclusives	0.05	17.70	40.98	26.16	48.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
All-Familial Exclusive	52	52	
Rare2MethodConsensus Exclusive	149	146	;SSPO;C4B_2
Overlap	8	8