Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) All-Familial Exclusive MI-Pathogenic 8.27e-01 3.41e-02 1.19e-07 5.13e-09 MI-Pathogenic Exclusive All-Familial 2.72e-03 4.32e-08 1.15e-14 6.18e-21 All-Familial Exclusive MI-Pathogenic Exclusive 9.83e-01 4.36e-02 1.09e-07 2.58e-08 MI-Pathogenic Exclusive All-Familial Exclusive 1.88e-03 8.50e-08 5.16e-13 5.10e-20 All-Familial Exclusive Overlap 9.92e-02 9.92e-02 9.92e-02 9.92e-02 MI-Pathogenic Exclusive Overlap 2.06e-01 2.06e-01 1.49e-01 2.17e-01 Overlap Exclusives 2.64e-10 2.44e-08 2.80e-15 1.22e-15 Evaluating how well All-Familial genes are linked to MI-Pathogenic genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) All-Familial Exclusive MI-Pathogenic 0.79 1.33 2.80 2.04 6.78 MI-Pathogenic Exclusive All-Familial 0.81 1.75 4.95 2.62 8.78 All-Familial Exclusive MI-Pathogenic Exclusive 0.78 1.16 3.05 1.97 5.89 MI-Pathogenic Exclusive All-Familial Exclusive 0.81 2.02 4.77 2.28 7.99 All-Familial Exclusive Overlap 1.00 1.51 2.51 1.71 1.89 MI-Pathogenic Exclusive Overlap 0.87 1.19 2.12 1.06 1.25 Overlap Exclusives 0.80 1.50 4.61 1.81 10.44 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) All-Familial Exclusive MI-Pathogenic 0.01 2.13 8.96 5.64 2.54 MI-Pathogenic Exclusive All-Familial 0.01 -0.27 2.51 3.80 11.18 All-Familial Exclusive MI-Pathogenic Exclusive 0.01 0.41 3.85 2.00 9.61 MI-Pathogenic Exclusive All-Familial Exclusive 0.01 -0.20 2.07 2.29 9.18 All-Familial Exclusive Overlap 0.03 28.02 475.31 85.62 47.54 MI-Pathogenic Exclusive Overlap 0.00 0.25 1.23 0.06 -0.03 Overlap Exclusives 0.04 13.81 28.43 7.05 61.77 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes All-Familial Exclusive 59 59 MI-Pathogenic Exclusive 38 38 Overlap 1 1