Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA-Somatic Exclusive	BRCA-Familial	3.72e-08	7.26e-05	9.58e-15	1.57e-12
BRCA-Familial Exclusive	BRCA-Somatic	1.05e-06	2.23e-06	6.28e-16	1.36e-20
BRCA-Somatic Exclusive	BRCA-Familial Exclusive	1.66e-04	8.23e-03	1.43e-11	1.31e-08
BRCA-Familial Exclusive	BRCA-Somatic Exclusive	1.02e-04	8.84e-05	6.14e-12	2.03e-17
BRCA-Somatic Exclusive	Overlap	2.62e-06	3.73e-05	2.62e-06	3.43e-06
BRCA-Familial Exclusive	Overlap	7.93e-05	4.56e-05	2.62e-06	4.10e-06
Overlap	Exclusives	1.11e-26	7.78e-22	3.99e-32	1.29e-28



Evaluating how well BRCA-Somatic genes are linked to BRCA-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic Exclusive	BRCA-Familial	0.94	1.14	4.55	2.70	7.37
BRCA-Familial Exclusive	BRCA-Somatic	0.94	2.38	5.86	3.59	9.80
BRCA-Somatic Exclusive	BRCA-Familial Exclusive	0.92	1.32	4.12	2.53	5.88
BRCA-Familial Exclusive	BRCA-Somatic Exclusive	0.93	2.20	4.82	3.84	9.05
BRCA-Somatic Exclusive	Overlap	0.99	1.87	2.72	2.51	3.77
BRCA-Familial Exclusive	Overlap	0.99	1.69	4.14	2.98	4.58
Overlap	Exclusives	0.96	4.39	10.53	3.15	10.93

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA-Somatic Exclusive	BRCA-Familial	0.03	0.11	11.49	10.87	51.83
BRCA-Familial Exclusive	BRCA-Somatic	0.02	0.55	13.05	11.42	58.68
BRCA-Somatic Exclusive	BRCA-Familial Exclusive	0.01	0.06	7.96	6.57	15.31
BRCA-Familial Exclusive	BRCA-Somatic Exclusive	0.01	0.40	7.15	11.83	40.93
BRCA-Somatic Exclusive	Overlap	0.03	0.34	13.53	31.59	1.38
BRCA-Familial Exclusive	Overlap	0.01	1.66	52.43	26.02	86.51
Overlap	Exclusives	0.13	25.02	162.73	56.46	243.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA-Somatic Exclusive	31	31	
BRCA-Familial Exclusive	17	17	
Overlap	6	6