Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MI-Pathogenic	AD-Final25	2.85e-04	2.01e-05	1.20e-08	2.89e-07
AD-Final25	MI-Pathogenic	2.32e-08	1.29e-06	2.81e-10	5.01e-12



Evaluating how well MI-Pathogenic genes are linked to AD-Final25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MI-Pathogenic	AD-Final25	0.79	3.45	4.59	2.42	4.83
AD-Final25	MI-Pathogenic	0.85	3.12	5.63	3.42	7.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MI-Pathogenic	AD-Final25	0.01	6.37	14.47	8.38	18.77
AD-Final25	MI-Pathogenic	0.02	6.21	27.05	13.32	6.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MI-Pathogenic	39	39	
AD-Final25	25	25