Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MI-Pathogenic Exclusive	All-Familial	6.52e-04	5.89e-08	5.46e-13	4.28e-20
All-Familial Exclusive	MI-Pathogenic	8.29e-01	4.29e-02	2.10e-08	1.76e-08
MI-Pathogenic Exclusive	All-Familial Exclusive	5.15e-04	1.12e-07	2.76e-13	5.64e-20
All-Familial Exclusive	MI-Pathogenic Exclusive	9.81e-01	4.28e-02	2.55e-07	1.13e-08
MI-Pathogenic Exclusive	Overlap	2.28e-01	3.20e-01	1.49e-01	2.17e-01
All-Familial Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	5.10e-10	2.33e-08	1.33e-14	1.44e-15



Evaluating how well MI-Pathogenic genes are linked to All-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MI-Pathogenic Exclusive	All-Familial	0.81	2.12	4.71	2.31	8.71
All-Familial Exclusive	MI-Pathogenic	0.79	1.36	3.46	2.45	5.68
MI-Pathogenic Exclusive	All-Familial Exclusive	0.81	2.17	4.76	2.61	7.73
All-Familial Exclusive	MI-Pathogenic Exclusive	0.78	1.30	2.94	2.03	5.71
MI-Pathogenic Exclusive	Overlap	0.87	1.11	1.52	1.22	1.27
All-Familial Exclusive	Overlap	1.00	1.35	2.46	1.60	1.77
Overlap	Exclusives	0.80	1.39	4.95	1.94	9.78

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MI-Pathogenic Exclusive	All-Familial	0.01	-0.14	2.61	2.45	12.16
All-Familial Exclusive	MI-Pathogenic	0.01	2.07	4.54	6.26	7.67
MI-Pathogenic Exclusive	All-Familial Exclusive	0.01	-0.11	2.81	2.30	9.28
All-Familial Exclusive	MI-Pathogenic Exclusive	0.01	0.90	3.40	1.17	5.43
MI-Pathogenic Exclusive	Overlap	0.00	0.04	0.79	0.10	-0.03
All-Familial Exclusive	Overlap	0.03	45.84	463.67	145.32	34.87
Overlap	Exclusives	0.04	13.52	33.78	6.55	54.31

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MI-Pathogenic Exclusive	38	38	
All-Familial Exclusive	59	59	
Overlap	1	1