Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MI-Pathogenic	BRCA-GWAS	3.69e-02	2.92e-02	3.54e-07	1.42e-06
BRCA-GWAS	MI-Pathogenic	4.65e-01	9.83e-01	4.58e-04	8.07e-05



Evaluating how well MI-Pathogenic genes are linked to BRCA-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MI-Pathogenic	BRCA-GWAS	0.62	-0.25	1.55	1.39	5.58
BRCA-GWAS	MI-Pathogenic	0.72	-0.98	0.01	0.48	3.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MI-Pathogenic	BRCA-GWAS	0.01	-1.12	0.72	1.53	3.95
BRCA-GWAS	MI-Pathogenic	0.01	-0.61	0.34	0.74	3.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MI-Pathogenic	39	39	
BRCA-GWAS	173	172