Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MI-Pathogenic	BRCA-Somatic	1.99e-01	2.13e-01	6.56e-05	1.50e-08
BRCA-Somatic	MI-Pathogenic	4.34e-01	1.21e-01	2.95e-06	4.89e-07



Evaluating how well MI-Pathogenic genes are linked to BRCA-Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MI-Pathogenic	BRCA-Somatic	0.81	-0.81	1.52	1.08	6.46
BRCA-Somatic	MI-Pathogenic	0.73	0.16	1.07	1.20	4.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MI-Pathogenic	BRCA-Somatic	0.01	-0.92	1.20	1.31	5.16
BRCA-Somatic	MI-Pathogenic	0.00	-0.58	-0.16	0.43	0.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MI-Pathogenic	39	39	
BRCA-Somatic	37	37