Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	React_AC40	2.14e-08	3.20e-02	2.82e-02	2.27e-06
React_AC40 Exclusive	Viral	1.60e-12	1.37e-02	3.94e-04	2.75e-04
Viral Exclusive	React_AC40 Exclusive	2.59e-08	3.89e-02	7.52e-02	4.15e-06
React_AC40 Exclusive	Viral Exclusive	3.90e-12	2.15e-02	7.64e-04	4.63e-04
Viral Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.38e-03
React_AC40 Exclusive	Overlap	2.79e-01	8.23e-01	8.50e-01	1.05e-01
Overlap	Exclusives	1.33e-09	2.44e-08	6.46e-20	3.96e-15



Evaluating how well Viral genes are linked to React_AC40 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	React_AC40	0.61	0.80	1.44	1.17	5.37
React_AC40 Exclusive	Viral	0.61	-2.02	-2.29	-0.68	3.67
Viral Exclusive	React_AC40 Exclusive	0.60	0.78	1.34	0.96	5.46
React_AC40 Exclusive	Viral Exclusive	0.61	-2.21	-2.10	-0.88	3.88
Viral Exclusive	Overlap	1.00	2.70	3.30	2.84	3.07
React_AC40 Exclusive	Overlap	0.70	-0.04	0.06	0.35	1.23
Overlap	Exclusives	0.67	0.85	4.68	0.87	9.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	React_AC40	0.01	0.67	0.49	0.83	1.82
React_AC40 Exclusive	Viral	0.01	-1.08	-1.68	-0.68	2.23
Viral Exclusive	React_AC40 Exclusive	0.01	0.09	-0.50	0.36	2.27
React_AC40 Exclusive	Viral Exclusive	0.01	-1.21	-1.74	-0.76	3.18
Viral Exclusive	Overlap	0.05	64.28	396.30	231.34	256.04
React_AC40 Exclusive	Overlap	0.00	-0.44	-0.56	-0.32	-0.04
Overlap	Exclusives	0.06	6.71	33.92	5.36	47.87

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	121	108	TNFα;FCER;UNC93B;SRY;HLA;IL12;Mig;HLA-DRB3;IFNL4;MBL3P;HLA-DRB4;HLA-Cw;SNORA31
React_AC40 Exclusive	202	202	
Overlap	3	3