Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova Exclusive	React_AC40	7.51e-16	9.87e-03	9.67e-02	1.15e-02
React_AC40 Exclusive	Casanova	1.37e-04	1.11e-01	1.05e-01	1.68e-01
Casanova Exclusive	React_AC40 Exclusive	6.90e-17	4.45e-03	6.71e-02	9.19e-03
React_AC40 Exclusive	Casanova Exclusive	2.65e-04	1.34e-01	1.01e-01	3.82e-01
Casanova Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
React_AC40 Exclusive	Overlap	3.02e-01	3.02e-01	2.66e-01	1.84e-01
Overlap	Exclusives	5.24e-10	6.00e-03	7.04e-02	5.86e-03



Evaluating how well Casanova genes are linked to React_AC40 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	React_AC40	0.54	-1.21	-3.76	-0.90	1.61
React_AC40 Exclusive	Casanova	0.61	-2.09	-1.14	-0.76	1.22
Casanova Exclusive	React_AC40 Exclusive	0.53	-1.31	-3.78	-0.90	1.62
React_AC40 Exclusive	Casanova Exclusive	0.58	-2.93	-1.63	-1.31	0.83
Casanova Exclusive	Overlap	1.00	2.62	3.54	2.00	3.03
React_AC40 Exclusive	Overlap	0.73	0.12	0.46	0.85	1.14
Overlap	Exclusives	0.55	-0.73	-3.10	-0.46	2.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	React_AC40	0.01	-0.95	-2.44	-0.75	0.20
React_AC40 Exclusive	Casanova	0.00	-0.73	-1.21	-0.58	0.01
Casanova Exclusive	React_AC40 Exclusive	0.01	-1.08	-2.84	-0.83	-0.34
React_AC40 Exclusive	Casanova Exclusive	0.00	-0.91	-1.65	-0.81	-0.16
Casanova Exclusive	Overlap	0.02	92.56	293.26	81.69	141.65
React_AC40 Exclusive	Overlap	0.00	-0.40	-0.30	-0.21	0.15
Overlap	Exclusives	0.02	0.32	2.70	0.79	5.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova Exclusive	11	10	UNC93B
React_AC40 Exclusive	203	203	
Overlap	2	2