Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	React_AC401	4.27e-11	9.49e-01	6.22e-03	1.12e-04
React_AC401 Exclusive	Viral	2.03e-09	7.90e-01	1.18e-02	1.90e-06
Viral Exclusive	React_AC401 Exclusive	6.04e-10	8.81e-01	1.16e-02	8.74e-05
React_AC401 Exclusive	Viral Exclusive	5.08e-10	6.86e-01	1.29e-02	9.52e-06
Viral Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
React_AC401 Exclusive	Overlap	6.06e-01	7.27e-01	9.82e-01	6.06e-01
Overlap	Exclusives	2.41e-08	3.25e-09	3.34e-18	7.55e-16



Evaluating how well Viral genes are linked to React_AC401 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	React_AC401	0.58	0.60	0.44	0.54	4.29
React_AC401 Exclusive	Viral	0.64	-1.82	-0.29	-0.32	5.06
Viral Exclusive	React_AC401 Exclusive	0.57	0.79	0.20	0.56	4.21
React_AC401 Exclusive	Viral Exclusive	0.63	-2.09	-0.26	-0.39	4.31
Viral Exclusive	Overlap	1.00	2.51	2.26	2.47	2.39
React_AC401 Exclusive	Overlap	0.69	-0.44	-0.12	0.41	0.78
Overlap	Exclusives	0.67	0.76	6.05	1.16	12.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	React_AC401	0.01	0.31	-0.60	0.26	2.05
React_AC401 Exclusive	Viral	0.01	-0.94	-1.12	-0.62	3.16
Viral Exclusive	React_AC401 Exclusive	0.01	0.38	-1.15	0.19	1.31
React_AC401 Exclusive	Viral Exclusive	0.01	-1.41	-0.91	-0.79	1.54
Viral Exclusive	Overlap	0.02	46.92	52.74	76.59	28.31
React_AC401 Exclusive	Overlap	0.00	-0.63	-0.53	-0.47	-0.06
Overlap	Exclusives	0.05	4.84	26.99	4.63	32.76

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	122	109	HLA-DRB4;SRY;FCER;HLA;IL12;HLA-Cw;UNC93B;MBL3P;SNORA31;TNFα;HLA-DRB3;Mig;IFNL4
React_AC401 Exclusive	217	217	
Overlap	2	2