Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	React_AC401	2.03e-08	5.34e-01	3.53e-03	1.54e-05
React_AC401 Exclusive	Covid	3.71e-06	6.64e-01	1.41e-01	1.24e-06
Covid Exclusive	React_AC401 Exclusive	1.45e-08	6.79e-01	6.46e-03	9.62e-06
React_AC401 Exclusive	Covid Exclusive	4.05e-06	7.00e-01	1.22e-01	2.55e-06
Covid Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
React_AC401 Exclusive	Overlap	5.90e-01	7.14e-01	2.52e-01	4.53e-01
Overlap	Exclusives	1.88e-05	1.53e-05	1.98e-07	3.36e-10



Evaluating how well Covid genes are linked to React_AC401 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	React_AC401	0.59	1.39	0.97	0.77	4.39
React_AC401 Exclusive	Covid	0.66	-1.60	0.84	-0.07	5.75
Covid Exclusive	React_AC401 Exclusive	0.58	1.20	0.65	0.73	4.30
React_AC401 Exclusive	Covid Exclusive	0.66	-1.48	0.71	-0.11	4.57
Covid Exclusive	Overlap	0.99	1.74	2.01	2.40	1.81
React_AC401 Exclusive	Overlap	0.66	0.30	0.28	1.31	0.60
Overlap	Exclusives	0.64	0.30	3.83	0.87	8.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	React_AC401	0.01	0.93	-0.35	0.34	1.54
React_AC401 Exclusive	Covid	0.01	-1.18	-0.20	-0.59	1.37
Covid Exclusive	React_AC401 Exclusive	0.01	0.59	-0.68	0.24	2.07
React_AC401 Exclusive	Covid Exclusive	0.01	-1.15	-0.15	-0.63	2.54
Covid Exclusive	Overlap	0.00	10.28	13.73	60.40	8.83
React_AC401 Exclusive	Overlap	0.00	-0.27	-0.28	0.52	-0.15
Overlap	Exclusives	0.04	1.35	18.35	3.19	23.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	85	81	HLA-DRB4;SRY;MBL3P;UNC93B
React_AC401 Exclusive	218	218	
Overlap	1	1