Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	STRING_AC401	1.65e-19	5.42e-01	1.95e-05	2.12e-01
STRING_AC401 Exclusive	Covid	5.09e-03	6.75e-03	3.33e-03	1.68e-09
Covid Exclusive	STRING_AC401 Exclusive	7.03e-20	3.95e-01	3.79e-06	2.50e-01
STRING_AC401 Exclusive	Covid Exclusive	5.24e-03	3.79e-03	5.12e-03	6.73e-10
Covid Exclusive	Overlap	1.42e-02	3.22e-02	1.15e-02	1.82e-02
STRING_AC401 Exclusive	Overlap	7.27e-01	9.70e-01	7.66e-01	9.54e-01
Overlap	Exclusives	8.09e-04	8.21e-04	8.20e-03	5.08e-06



Evaluating how well Covid genes are linked to STRING_AC401 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	STRING_AC401	0.50	0.53	-0.82	-0.16	-0.37
STRING_AC401 Exclusive	Covid	0.71	0.71	2.07	0.67	7.58
Covid Exclusive	STRING_AC401 Exclusive	0.49	0.64	-1.01	-0.54	-0.30
STRING_AC401 Exclusive	Covid Exclusive	0.72	0.54	2.39	0.57	6.98
Covid Exclusive	Overlap	0.96	5.03	2.77	2.86	2.41
STRING_AC401 Exclusive	Overlap	0.51	1.08	0.30	1.09	0.04
Overlap	Exclusives	0.55	0.60	2.72	1.06	3.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	STRING_AC401	0.02	2.05	0.69	0.83	0.67
STRING_AC401 Exclusive	Covid	0.01	-0.32	2.96	-0.12	6.79
Covid Exclusive	STRING_AC401 Exclusive	0.02	2.23	0.49	0.36	0.66
STRING_AC401 Exclusive	Covid Exclusive	0.01	-0.44	3.06	-0.24	8.75
Covid Exclusive	Overlap	0.00	16.19	1.07	20.76	3.30
STRING_AC401 Exclusive	Overlap	0.00	0.21	-0.20	0.31	-0.27
Overlap	Exclusives	0.04	2.57	11.38	3.38	11.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	84	80	UNC93B;MBL3P;HLA-DRB4;SRY
STRING_AC401 Exclusive	396	396	
Overlap	2	2