Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova Exclusive	STRING_AC401	4.74e-32	2.39e-04	5.06e-01	2.88e-04
STRING_AC401 Exclusive	Casanova	2.32e-01	1.39e-01	2.46e-01	1.93e-04
Casanova Exclusive	STRING_AC401 Exclusive	1.81e-33	1.68e-04	4.61e-01	1.05e-04
STRING_AC401 Exclusive	Casanova Exclusive	1.91e-01	1.27e-01	1.64e-01	1.50e-04
Casanova Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
STRING_AC401 Exclusive	Overlap	1.85e-01	3.35e-01	2.40e-01	5.90e-01
Overlap	Exclusives	2.00e-06	3.08e-01	8.82e-07	2.03e-01



Evaluating how well Casanova genes are linked to STRING_AC401 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	STRING_AC401	0.47	-1.68	-3.38	-1.30	-2.13
STRING_AC401 Exclusive	Casanova	0.79	0.51	2.20	0.72	3.51
Casanova Exclusive	STRING_AC401 Exclusive	0.47	-2.03	-3.13	-1.17	-2.16
STRING_AC401 Exclusive	Casanova Exclusive	0.80	0.47	1.98	0.62	3.97
Casanova Exclusive	Overlap	1.00	2.75	2.50	2.08	1.87
STRING_AC401 Exclusive	Overlap	0.69	1.58	0.67	1.30	0.48
Overlap	Exclusives	0.49	-0.52	-1.60	-0.83	-0.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	STRING_AC401	0.02	-0.05	-0.57	-0.15	-0.50
STRING_AC401 Exclusive	Casanova	0.00	-0.14	2.38	0.02	1.81
Casanova Exclusive	STRING_AC401 Exclusive	0.02	-0.47	-0.88	-0.33	-0.82
STRING_AC401 Exclusive	Casanova Exclusive	0.00	-0.10	2.80	0.11	1.15
Casanova Exclusive	Overlap	0.01	160.07	76.43	16.19	21.34
STRING_AC401 Exclusive	Overlap	0.00	0.83	-0.12	0.47	-0.24
Overlap	Exclusives	0.03	1.54	4.49	1.91	4.74

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova Exclusive	12	11	UNC93B
STRING_AC401 Exclusive	397	397	
Overlap	1	1