Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	STRING_AC40	1.58e-28	5.26e-01	4.07e-06	8.11e-03
STRING_AC40 Exclusive	Viral	3.61e-05	2.68e-03	1.13e-08	3.12e-20
Viral Exclusive	STRING_AC40 Exclusive	4.32e-29	4.40e-01	2.89e-05	8.45e-03
STRING_AC40 Exclusive	Viral Exclusive	6.58e-05	1.93e-03	5.35e-08	7.73e-20
Viral Exclusive	Overlap	2.69e-04	1.59e-03	1.77e-04	7.14e-04
STRING_AC40 Exclusive	Overlap	4.57e-01	9.41e-01	2.80e-01	3.73e-01
Overlap	Exclusives	2.81e-09	4.37e-09	1.65e-15	1.54e-15



Evaluating how well Viral genes are linked to STRING_AC40 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	STRING_AC40	0.54	0.28	-0.06	1.05	2.54
STRING_AC40 Exclusive	Viral	0.77	2.31	4.30	2.56	9.98
Viral Exclusive	STRING_AC40 Exclusive	0.54	0.05	-0.31	0.74	2.73
STRING_AC40 Exclusive	Viral Exclusive	0.77	2.12	4.72	2.19	9.48
Viral Exclusive	Overlap	0.96	4.93	2.97	3.82	3.26
STRING_AC40 Exclusive	Overlap	0.65	1.49	0.66	1.69	1.13
Overlap	Exclusives	0.61	1.86	5.58	1.99	9.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	STRING_AC40	0.03	5.32	3.47	3.34	4.90
STRING_AC40 Exclusive	Viral	0.02	0.92	4.25	2.36	9.55
Viral Exclusive	STRING_AC40 Exclusive	0.02	4.01	2.35	2.88	4.37
STRING_AC40 Exclusive	Viral Exclusive	0.02	0.80	3.80	1.91	23.22
Viral Exclusive	Overlap	0.00	44.26	2.54	34.45	21.67
STRING_AC40 Exclusive	Overlap	0.00	4.02	0.77	5.87	0.59
Overlap	Exclusives	0.05	4.31	22.05	7.43	26.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	120	107	HLA-DRB3;MBL3P;SNORA31;SRY;FCER;IL12;IFNL4;UNC93B;HLA;HLA-DRB4;HLA-Cw;TNFα;Mig
STRING_AC40 Exclusive	389	388	PRAG1
Overlap	4	4