Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	STRING_AC40	3.48e-30	6.91e-02	1.11e-05	6.85e-03
STRING_AC40 Exclusive	Covid	2.97e-04	1.06e-03	9.53e-08	3.83e-15
Covid Exclusive	STRING_AC40 Exclusive	2.15e-30	3.38e-02	3.94e-05	6.90e-03
STRING_AC40 Exclusive	Covid Exclusive	2.42e-04	1.29e-03	4.84e-08	2.99e-15
Covid Exclusive	Overlap	1.45e-03	3.70e-03	1.38e-03	3.23e-03
STRING_AC40 Exclusive	Overlap	5.32e-01	7.84e-01	3.08e-01	7.54e-01
Overlap	Exclusives	6.97e-09	2.03e-06	5.64e-06	7.34e-12



Evaluating how well Covid genes are linked to STRING_AC40 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	STRING_AC40	0.53	-0.47	-1.05	0.57	2.16
STRING_AC40 Exclusive	Covid	0.77	1.30	3.67	1.80	8.09
Covid Exclusive	STRING_AC40 Exclusive	0.53	-0.93	-1.40	0.25	1.97
STRING_AC40 Exclusive	Covid Exclusive	0.78	1.21	3.52	1.58	7.89
Covid Exclusive	Overlap	0.97	4.91	2.95	3.00	3.03
STRING_AC40 Exclusive	Overlap	0.54	0.91	0.51	1.21	0.31
Overlap	Exclusives	0.60	1.94	4.17	1.47	7.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	STRING_AC40	0.03	4.14	2.78	3.75	5.19
STRING_AC40 Exclusive	Covid	0.02	0.45	2.67	2.00	7.28
Covid Exclusive	STRING_AC40 Exclusive	0.02	2.53	2.34	3.72	3.90
STRING_AC40 Exclusive	Covid Exclusive	0.02	0.34	2.37	1.91	8.73
Covid Exclusive	Overlap	0.01	50.39	2.34	40.11	4.26
STRING_AC40 Exclusive	Overlap	0.00	0.65	-0.21	0.84	-0.27
Overlap	Exclusives	0.04	5.22	15.12	4.58	17.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	83	79	SRY;HLA-DRB4;UNC93B;MBL3P
STRING_AC40 Exclusive	390	389	PRAG1
Overlap	3	3