Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	STRING_AC40	3.34e-22	1.34e-01	7.76e-02	2.57e-02
STRING_AC40	Casanova	9.75e-03	1.05e-02	3.29e-03	9.08e-06



Evaluating how well Casanova genes are linked to STRING_AC40 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	STRING_AC40	0.53	-0.79	-1.53	-0.42	1.61
STRING_AC40	Casanova	0.85	1.26	3.02	1.25	4.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	STRING_AC40	0.02	0.78	1.02	0.96	1.92
STRING_AC40	Casanova	0.00	1.00	6.73	1.92	7.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
STRING_AC40	393	392	PRAG1